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We further employed the elevated zero maze to evaluate compromised anxiety-like behavior and their risk-assessment behavior, based on the premise that exposure to an elevated open platform generally elicits heightened anxiety responses (Fig

Its high intracellular concentration (typically ranging from 1 to 10 mM) and the reactive thiol group of its cysteine residue make it a highly effective antioxidant

Mechanistically, iron reacts with PLOOH to generate the free radicals PLO and PLOO , which propagate peroxidation chain reactions (Reference Conrad and Pratt4)

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A growing body of research has demonstrated the potential of inhibiting ferroptosis in the management of pain [19, 47, 100]